Pain, Its Anatomy, Physiology and Treatment: Second Edition by Aage Moller

Author:Aage Moller [Moller, Aage]
Language: eng
Format: azw3
Publisher: Aage R. Møller Publishing
Published: 2014-05-31T04:00:00+00:00

Reorganization of central pain pathways

It has been shown recently that there are many connections between different parts of the brain and the a specific task is not carried out only in a certain region of the brain but many parts are connected and involved in processing of information and generating commands. As an example it has been shown that much larger cortical regions are involved in simple tasks such as interpretation of a spoken word [440].

It was assumed earlier that diseases were caused by malfunction of a specific of the brain. That is not correct either and evidence has been presented that malfunction of many parts of the brain is involved in generating symptoms of disease. It has also been shown that these connections are dynamic, meaning that they can change. It is now believed that altered connections are in many cases signs of pathologies. There are recent studies that indicate that changes in connections between different parts of the brain are involved in age related changes [21, 377, 378] and in causing symptoms of disease [17, 379]

Recent studies have shown evidence of strong involvement of the state of the motivational and emotional mesolimbic-prefrontal circuitry of the brain. Nociceptive inputs elicit plastic changes within this circuitry are involved in shifting the pattern of brain involvement from acute pain to chronic pain thereby making the pain less somatic and more affective in nature [248].

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